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Related Experiment Videos

Enterotoxigenic Bacteroides fragilis

C L Sears1, L L Myers, A Lazenby

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 1, 1995
PubMed
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Enterotoxigenic Bacteroides fragilis (ETBF) causes watery diarrhea by secreting a toxin that disrupts intestinal cells. This toxin alters cell shape and detachment, impacting gut health in animals and children.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Pathogenesis

Background:

  • Enterotoxigenic Bacteroides fragilis (ETBF) is linked to watery diarrheal disease.
  • ETBF produces an extracellular heat-labile toxin (~20 kD).

Purpose of the Study:

  • To investigate the biological activities of the ETBF toxin.
  • To understand the toxin's role in intestinal epithelial cell morphology and secretion.

Main Methods:

  • Testing toxin effects on ligated intestinal segments in lambs and calves.
  • Evaluating toxin-induced changes in intestinal epithelial cell lines in vitro.

Main Results:

  • The ETBF toxin stimulated secretion in ligated intestinal segments.
  • In vitro, the toxin altered intestinal epithelial cell morphology, causing rounding and detachment.

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  • In vivo, ETBF infection disrupted colonic epithelium with swollen surface cells.

    • Conclusions:

    • The ETBF toxin acts as a secretory, cytoskeleton-altering toxin.
    • Further research is needed to determine the toxin's precise contribution to ETBF-associated diarrhea pathogenesis.