Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement biosynthesis in the central nervous system

S R Barnum1

  • 1Department of Microbiology, University of Alabama at Birmingham 35294, USA.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma levels of soluble membrane attack complex are elevated despite viral suppression in HIV patients with poor immune reconstitution.

Clinical and experimental immunology·2019
Same author

Membrane attack complex generation increases as a function of time in stored blood.

Transfusion medicine (Oxford, England)·2014
Same author

Deletion of the complement phagocytic receptors CR3 and CR4 does not alter susceptibility to experimental cerebral malaria.

Parasite immunology·2012
Same author

Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.

Parasite immunology·2012
Same author

Excision of the nifD element in the heterocystous cyanobacteria.

Archives of microbiology·2008
Same author

Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage.

Brain research·2001
Same journal

Oral health, atherosclerosis, and cardiovascular disease.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
Same journal

The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
Same journal

Pathogenesis of apical periodontitis and the causes of endodontic failures.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
Same journal

The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
Same journal

TGF-beta signal transduction in oro-facial health and non-malignant disease (part I).

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
Same journal

It is time to move on.....

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists·2004
See all related articles

The complement system, crucial for immunity, is produced by various brain cells like astrocytes. Its role in neurological diseases highlights the need to understand its CNS regulation for potential therapies.

Area of Science:

  • Neuroimmunology
  • Molecular Immunology

Background:

  • The complement system is a key component of the innate and adaptive immune response.
  • Complement activation fragments mediate diverse immune functions, including inflammation and opsonization.
  • Growing evidence links complement system dysregulation to neurological diseases like Alzheimer's and multiple sclerosis.

Purpose of the Study:

  • To investigate the expression and regulation of complement components within the central nervous system (CNS).
  • To explore the role of different CNS cell types in complement synthesis and function.
  • To understand the implications of CNS complement activity in neurological disorders.

Main Methods:

  • In vitro studies analyzing complement protein expression by astrocytes.
  • Examination of complement component regulation by pro- and anti-inflammatory cytokines.

Related Experiment Videos

  • Identification of complement protein synthesis and receptor expression in various CNS cell types (astrocytes, ependymal cells, endothelial cells, microglia, neurons).

    • Main Results:

    • Astrocytes, the primary glial cells, can express and produce a majority of complement system components.
    • Expression of astrocyte-derived complement proteins is modulated by pro- and anti-inflammatory cytokines.
    • Multiple CNS cell types, including neurons and microglia, synthesize complement proteins or express complement receptors.
    • Complement expression in several brain cell types increases in response to acute phase response mediators.

    Conclusions:

    • The central nervous system possesses a significant capacity for complement production involving multiple cell types.
    • Complement plays a potentially larger role in CNS immune responses than previously recognized.
    • Understanding CNS complement dynamics offers therapeutic avenues for inflammatory and degenerative neurological diseases.