Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-12

T Germann1, E Rüde

  • 1Institute for Immunology, Mainz, Germany.

International Archives of Allergy and Immunology
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Interleukin-12 (IL-12) is a key cytokine connecting innate and acquired immunity, crucial for T cell differentiation and immune responses against infections and tumors. This review details its regulation, activity, and role in diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A 50-year-old man with ankle pain].

Der Radiologe·2017
Same author

Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.

British journal of pharmacology·2004
Same author

Thalidomide impairment of trinitrobenzene sulphonic acid-induced colitis in the rat - role of endothelial cell-leukocyte interaction.

British journal of pharmacology·2001
Same author

CD154 stimulation of interleukin-12 synthesis in human endothelial cells.

European journal of immunology·2000
Same author

Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2000
Same author

Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells.

Gastroenterology·1999

Area of Science:

  • Immunology
  • Cytokine Biology
  • Infectious Disease Research

Background:

  • Interleukin-12 (IL-12) was initially identified as a factor from B cell lines, also known as cytotoxic lymphocyte maturation factor and natural killer (NK) cell stimulatory factor.
  • A murine factor, T cell-stimulating factor (TSF), involved in CD4+ Th1 cell proliferation and IFN-gamma synthesis, was found to be identical to IL-12.
  • Monocytes and macrophages are primary sources of IL-12, rapidly produced by phagocytic cells upon microbial stimulation.

Purpose of the Study:

  • To review the broad activities of IL-12, including its effects on T and NK cells, hematopoiesis, and immune responses.
  • To focus on recent findings regarding IL-12 production and activity regulation.
  • To explore IL-12's role in Th cell differentiation, hypersensitivity reactions, autoimmune diseases, and its potential inhibitory mechanisms.

Related Experiment Videos

Main Methods:

  • Literature review summarizing existing research on IL-12.
  • Analysis of studies on IL-12's effects in vitro and in vivo.
  • Focus on recent experimental results concerning IL-12 regulation and function.

Main Results:

  • IL-12 connects innate and acquired immunity, influencing NK cells, CD4+ and CD8+ T cells.
  • In vivo application of IL-12 enhances resistance to infections, promotes antitumor immunity, and affects antiviral responses.
  • IL-12 is critical for Th1 cell development and has implications for hypersensitivity and autoimmune diseases.

Conclusions:

  • IL-12 is a pleiotropic cytokine with significant roles in regulating cellular immunity and host defense.
  • Understanding IL-12's regulation and activity is crucial for its therapeutic potential in infectious, autoimmune, and neoplastic diseases.
  • The IL-12p40 homodimer may act as a specific inhibitor of the active IL-12 heterodimer, suggesting complex regulatory mechanisms.