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Morphological classification of renal cancer
1Gerhard Domagk-Institute of Pathology, Westfälische Wilhelms-Universität, Münster, Germany.
World Journal of Urology
|January 1, 1995
Summary
This study classifies renal tumors into eight types based on cell and tumor features. Cytogenetic data support these classifications and offer insights into tumor development and progression.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Current renal-cell adenoma (RCA) and carcinoma (RCC) classification relies on eight distinct morphologic entities.
- These entities include clear-cell, chromophilic, chromophobic, duct Bellini, transitional-cell, neuroendocrine, oncocytic, and metanephroid types.
Purpose of the Study:
- To detail the eight morphologic subtypes of renal cell tumors.
- To correlate cytogenetic data with proposed histogenesis and tumor subtypes.
- To provide insights into the specific development and progression of different renal tumor types.
Main Methods:
- Morphologic analysis of renal cell tumors.
- Classification based on established criteria for eight distinct entities.
- Analysis of tumor cytogenetics data.
Main Results:
- The eight morphologic subtypes of RCAs and RCCs are defined.
- Clear-cell and chromophilic tumors, originating from the proximal tubule, constitute 85% of renal cancers.
- Chromophobic, oncocytic, and duct Bellini tumors, originating from the connecting tubule/collecting duct, represent 11% of renal cancers.
- Rare tumor types constitute less than 1% each.
- Cytogenetic data align with and support the proposed morphologic subtypes.
Conclusions:
- The established classification of renal cell tumors into eight morphologic subtypes is supported by cytogenetic findings.
- Cytogenetic data offer further understanding of type-specific tumor development and progression in the kidney.
- This classification aids in understanding the histogenesis and behavior of various renal neoplasms.