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Rhinoviruses and cells: molecular aspects

D J Rowlands1

  • 1Wellcome Foundation Ltd., Kent, United Kingdom.

American Journal of Respiratory and Critical Care Medicine
|October 1, 1995
PubMed
Summary

Structural insights into human rhinoviruses advance our understanding of viral mechanisms. Despite progress in molecular virology, a cure for the common cold remains elusive.

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Area of Science:

  • Molecular virology
  • Structural biology

Background:

  • Human rhinoviruses are a major cause of the common cold.
  • Understanding their molecular structure and function is key to developing interventions.

Purpose of the Study:

  • To review recent developments in understanding human rhinovirus structure and function.
  • To highlight how structural data informs viral mechanisms and replication.

Main Methods:

  • Near atomic resolution determination of virus structure.
  • Molecular techniques for analyzing viral nucleic acids and proteins.

Main Results:

  • Structural data provides insights into capsid assembly, attachment, uncoating, and neutralization.
  • Molecular techniques reveal details of the viral replication machinery.
  • Host-viral component interactions during infection are not fully understood.

Conclusions:

  • Advances in structural and molecular biology offer new perspectives on human rhinovirus.
  • A definitive cure for the common cold is still an ongoing challenge.

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