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Genome organization in the caliciviridae
1Molecular Microbiology Group, University of Southampton Medical School, Southampton General Hospital, UK.
Trends in Microbiology
|July 1, 1995
Summary
Caliciviruses cause significant diseases and possess a positive-sense single-stranded RNA genome. This review details the genome organization and evolutionary links of animal and human caliciviruses.
Area of Science:
- Virology
- Genomics
Background:
- Caliciviruses are responsible for a range of significant animal and human diseases.
- Understanding their genetic makeup is crucial for disease control and prevention.
Purpose of the Study:
- To review the genome organization of caliciviruses.
- To outline the phylogenetic relationships among animal and human caliciviruses.
Main Methods:
- Analysis of recently determined complete genome sequences of various caliciviruses.
- Comparative genomics and phylogenetic analysis.
Main Results:
- Caliciviruses share a positive-sense single-stranded RNA genome structure.
- Established phylogenetic relationships provide insights into their evolution and host adaptation.
Conclusions:
- The genomic information and phylogenetic analysis are essential for understanding calicivirus diversity and pathogenicity.
- This review consolidates current knowledge on calicivirus genomes, aiding future research and therapeutic strategies.