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Related Experiment Videos

Macroscopically node-negative but histologically node-positive gastric carcinoma

Y Adachi1, M Mori, Y Maehara

  • 1Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

The British Journal of Surgery
|September 1, 1995
PubMed
Summary
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Macroscopically node-negative but histologically node-positive (N(-) n(+)) gastric tumors show a 66% 10-year survival rate. This finding indicates that the number of positive lymph nodes and disease stage are key prognostic indicators for these specific gastric cancer cases.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Gastric Carcinogenesis

Background:

  • Gastric carcinoma staging traditionally relies on macroscopic and histologic lymph node assessment.
  • A subset of gastric tumors presents as macroscopically node-negative but histologically node-positive (N(-) n(+)).

Purpose of the Study:

  • To investigate the clinicopathological features and prognostic implications of N(-) n(+) gastric tumors.
  • To determine the survival outcomes associated with N(-) n(+) tumors compared to other nodal status categories.

Main Methods:

  • Retrospective analysis of 521 patients with gastric carcinoma undergoing curative surgery.
  • Evaluation of macroscopic and histologic lymph node status, tumor size, invasion depth, lymph node metastasis group, number of positive nodes, and disease stage.

Related Experiment Videos

  • Kaplan-Meier survival analysis to compare 10-year survival rates.

    • Main Results:

    • 62 out of 240 (26%) histologically node-positive tumors were classified as N(-) n(+).
    • The 10-year survival rate for N(-) n(+) tumors was 66%, significantly worse than node-negative (91%) but better than node-positive (40%) tumors (P < 0.01).
    • N(-) n(+) tumors were characterized by smaller size (<5 cm), limited invasion (muscularis propria), metastasis to group 1 nodes, fewer than seven positive nodes, and stage II disease.

    Conclusions:

    • N(-) n(+) gastric tumors represent an intermediate prognostic group with a better outcome than histologically node-positive disease.
    • Survival in N(-) n(+) gastric cancer is influenced by the number of positive lymph nodes and the overall stage of the disease.
    • The number of positive lymph nodes serves as a crucial prognostic indicator in patients with N(-) n(+) gastric carcinoma.