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Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors
C Y Lee1, K L Double, A D Crocker
1Department of Clinical Pharmacology, Flinders University of South Australia, Adelaide.
Brain Research
|May 29, 1995
Abstract:
Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2 receptor agonist, apomorphine. The results support the hypothesis that D1 receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour.