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Hypertonic/hyperoncotic fluids reverse prostaglandin E2 (PGE2)-induced T-cell suppression
R Coimbra1, W G Junger, F C Liu
1Department of Surgery, University of California San Diego 92103-8896, USA.
Shock (Augusta, Ga.)
|July 1, 1995
Summary
Hypertonic saline (HTS) and hypertonic saline-dextran (HSD) boost T-cell proliferation and reverse immune suppression. These fluids may help reduce infection risk in patients by improving immune function.
Area of Science:
- Immunology
- Intravenous Fluid Therapy
Background:
- Conventional isotonic fluids are being re-evaluated for immune function effects.
- Hypertonic and hyperoncotic fluids are potential alternatives.
Purpose of the Study:
- To investigate the impact of common intravenous fluids on human immune cell proliferation.
- To assess the effects of hypertonic saline (HTS), hypertonic saline-dextran (HSD), dextran (Dx), albumin (ALB), and hydroxyethylstarch (HET) on T-cell function.
Main Methods:
- In vitro testing of fluid effects on phytohemagglutinin-stimulated human peripheral blood mononuclear cells.
- Evaluation of normal and prostaglandin E2-suppressed T-cell proliferation.
Main Results:
- HTS, HSD, and ALB significantly enhanced T-cell proliferation at clinically relevant concentrations.
- HTS reversed prostaglandin E2-induced T-cell suppression.
- Dx and HET showed minimal effects on T-cell proliferation.
Conclusions:
- Hypertonic/hyperoncotic solutions, particularly HTS and HSD, may improve T-cell function.
- These fluids could mitigate prostaglandin-mediated immune suppression in patients.
- Potential use as an adjunct therapy to reduce infection risk.