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[Liver disease in systemic lupus erythematosus]
A Suzuki1, N Sekiyama, N Koito
1Department of Internal Medicine, Kawasaki Municipal Hospital.
Insights
Systemic lupus erythematosus (SLE) patients frequently experience liver disease, with 40.4% showing abnormal transaminases. While liver issues are common in SLE, severe cases were not observed in this study.
Area of Science:
- Hepatology
- Rheumatology
- Internal Medicine
Context:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Liver involvement is a recognized, though less common, manifestation of SLE.
- Understanding the spectrum of liver disease in SLE patients is crucial for comprehensive patient care.
Purpose:
- To analyze the prevalence and types of liver disease in patients with systemic lupus erythematosus (SLE).
- To identify SLE as a potential cause of liver disease in the absence of other identifiable etiologies.
- To characterize the clinical presentation and severity of liver disease in an SLE cohort.
Summary:
- A retrospective analysis of 193 patients with SLE revealed abnormal transaminase levels in 40.4% (78 patients).
- Among these, 35 patients had identified liver diseases, with 12 cases attributed to SLE alone.
- Other diagnosed liver conditions included fatty liver, viral infections, gallstones, drug allergies, autoimmune hepatitis, and primary biliary cirrhosis; no severe cases were reported.
Impact:
- Highlights the significant frequency of liver abnormalities in SLE patients.
- Suggests SLE itself can be an independent cause of liver disease.
- Indicates that while liver disease is common in SLE, it may often present in a non-severe form.
Abstract:
Liver disease in 193 patients (17 male and 176 female) with systemic lupus erythematosus (SLE) at Kawasaki Municipal Hospital were analyzed. Abnormal transaminase levels were found in 78 case (40.4%). Among them, there were 35 patients whose liver disease were identified. There were 12 patients whom no cause could be found other than SLE. Other liver disease were as follows: fatty liver in 9 cases, virus infection in 5 cases, gall stone and/or cholecystitis in 3 cases, drug allergy in 2 cases, autoimmune hepatitis 2 cases, primary biliary cirrhoses in 1 case. Liver disease with systemic lupus erythematosus was frequent, but there was no severe case.