Sterility in neonatally androgenized female rats and the decidual cell reaction

In female rats, administration of androgen during early postnatal life results in anovulatory sterility characterized by polyfollicular ovaries and persistent vaginal cornification in adulthood. In these androgen-sterilized rats, the acyclic male pattern of gonadotropin secretion results from permanent damage to hypothalamic centers normally responsive to steroid feedback. The capacity of the endometrium to differentiate into deciduoma in response to endometrial stimulation is markedly reduced in the uterus of the androgenized rats receiving an appropriate regimen of progesterone and estrogen injections. The hypothesis is presented that the lowered uterine responsiveness in the androgenized rats is largely ascribable to the effect of androgen given neonatally rather than to the influence of continued exposure to ovarian estrogen. This review deals with the nature of the uterine response to ovarian hormones and the deciduogenic stimulus in androgenized rats in order to verify the mechanism involved in androgen action on the neonatal uterus.