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Treatment planning optimization for multiple arcs stereotactic radiosurgery using a linear accelerator

C F Lam1, J G Zhu, J O Fenn

  • 1Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston 29425, USA.

International Journal of Radiation Oncology, Biology, Physics
|October 15, 1995
PubMed
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Optimizing collimator size and isocenter location in multiarc stereotactic radiosurgery significantly improves treatment plan conformity. This advanced method enhances tumor targeting while minimizing damage to surrounding healthy tissue.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Neurosurgery

Background:

  • Multiarc stereotactic radiosurgery (SRS) is a precise technique for intracranial tumor irradiation.
  • Conventional SRS treatment planning relies on time-consuming, suboptimal trial-and-error methods.
  • Nonconformal dose distributions arise from using uniform collimator sizes across all treatment arcs.

Purpose of the Study:

  • To introduce an optimized method for three-dimensional (3D) treatment dose planning in multiarc SRS.
  • To evaluate the efficacy of optimizing collimator size and isocenter coordinates for improved dose conformity.

Main Methods:

  • A derivative-free optimization algorithm was employed to determine optimal collimator sizes for individual arcs.
  • The optimization process also determined the ideal 3D coordinates for radiation isocenters.

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  • This approach contrasts with traditional methods using fixed collimator sizes and manual adjustments.

    • Main Results:

    • Optimized treatment plans demonstrated superior conformity of the 90% isodose curve to tumor volumes.
    • Conventional methods resulted in either incomplete tumor coverage or excessive irradiation of normal tissues.
    • Evaluations included artificial spherical and ellipsoidal tumors, as well as one actual clinical tumor case.

    Conclusions:

    • Optimizing individual arc collimator sizes and isocenter locations significantly enhances dose conformity in multiarc SRS.
    • The proposed optimization method yields superior treatment plans compared to conventional approaches.
    • Improved conformity leads to better tumor targeting and reduced exposure of healthy brain tissue.