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Comparison of rufloxacin and norfloxacin effects on faecal flora
F Marco1, M J Giménez, M T Jiménez de Anta
1Microbiology Department, Hospital Clinic i Provincial, Barcelona, Spain.
The Journal of Antimicrobial Chemotherapy
|June 1, 1995
Abstract:
The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused > 70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).