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Plasma androgens in autism

S Tordjman1, G M Anderson, P A McBride

  • 1Department of Psychiatry, Université de Paris-Sud, France.

Journal of Autism and Developmental Disorders
|June 1, 1995
PubMed
Summary
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Altered androgen secretion is not typical in autism spectrum disorder (ASD). However, individuals with cerebral palsy may show abnormalities in adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) levels.

Area of Science:

  • Endocrinology
  • Neurodevelopmental Disorders
  • Autism Research

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
  • Hormonal imbalances, particularly in androgens like testosterone and dehydroepiandrosterone sulfate (DHEA-S), have been investigated in relation to ASD.
  • Previous research has yielded inconsistent findings regarding androgen levels in individuals with autism.

Purpose of the Study:

  • To investigate and compare plasma levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S) in male individuals with autism, intellectual disability, and typically developing controls.
  • To explore potential correlations between androgen levels, serotonin, and pubertal status in these groups.

Main Methods:

  • Measurement of plasma testosterone and DHEA-S levels in prepubertal and postpubertal male subjects across three groups: autistic, mentally retarded/cognitively impaired (MR), and normal controls (NC).

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  • Statistical analysis to compare hormone levels between groups and assess correlations between testosterone and whole blood serotonin (5-HT).

    • Main Results:

    • No significant differences in mean plasma testosterone or DHEA-S levels were found between postpubertal autistic and normal control groups.
    • Prepubertal autistic, MR, and NC individuals also showed no significant group differences in these androgens.
    • Prepubertal MR individuals with cerebral palsy exhibited elevated plasma DHEA-S levels compared to controls.
    • Significant negative correlations were observed between testosterone and whole blood serotonin (5-HT) in the combined and autistic groups.

    Conclusions:

    • Altered secretion of androgens, including testosterone and DHEA-S, does not appear to be a common characteristic of autism spectrum disorder.
    • Abnormalities in adrenal androgen secretion may be associated with cerebral palsy.
    • The relationship between testosterone, puberty, and serotonin warrants further investigation.