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Autonomic dysfunction in the Landry-Guillain-Barre syndrome
Clinical and Experimental Neurology
|January 1, 1978
Summary
Autonomic nervous system dysfunction is common in Landry-Guillain-Barré syndrome, affecting both sympathetic and parasympathetic functions. This study found abnormal sweating, postural hypotension, and reduced baroreflex sensitivity in patients.
Area of Science:
- Neurology
- Autonomic Neuroscience
Background:
- Landry-Guillain-Barré syndrome (GBS) is an autoimmune disorder primarily affecting peripheral nerves.
- Autonomic dysfunction is a recognized but not fully characterized complication of GBS.
Purpose of the Study:
- To investigate the extent and nature of autonomic nervous system involvement in patients with Landry-Guillain-Barré syndrome.
- To assess sympathetic and parasympathetic functions using objective clinical tests.
Main Methods:
- Evaluated 7 GBS patients and 5 healthy controls.
- Performed autonomic function tests including sweat response, postural hypotension measurements, and baroreflex sensitivity assessment.
Main Results:
- Abnormal sweating was observed in 5 out of 7 GBS patients.
- Postural hypotension was present in 4 patients.
- Baroreflex sensitivity was significantly reduced in GBS patients compared to controls (p < 0.01).
Conclusions:
- Autonomic nervous system impairment, involving both sympathetic and parasympathetic branches, is a significant feature of Landry-Guillain-Barré syndrome.
- These findings highlight the importance of assessing autonomic function in GBS management and prognosis.