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Fatal necrotizing pancreatitis caused by hepatitis B virus infection in a liver transplant recipient
A Cavallari1, M Vivarelli, A D'Errico
1Second Department of Surgery, University of Bologna, S. Orsola Hospital, Italy.
Journal of Hepatology
|June 1, 1995
Abstract:
A 32-year-old man who had undergone liver transplantation for fulminant hepatitis due to HBV infection developed fatal acute necrotizing pancreatitis on the 60th post-transplant day, while showing signs of intense viral replication. Immunohistochemistry and in situ hybridization of the pancreas following autopsy showed the presence of HBsAG and HBV-DNA in the cytoplasm of acinar cells, together with the picture of necrotizing pancreatitis. Clinical and histological features seem to indicate that pancreatitis was directly caused by HBV infection.