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Combination finasteride and flutamide in advanced carcinoma of the prostate: effective therapy with minimal side
1Division of Urology, University of Toronto, Canada.
Purpose:
The efficacy of the combination of finasteride and flutamide in select patients with advanced prostatic cancer is determined.
Materials And Methods:
A total of 22 sexually active patients with stages C and D1 carcinoma of the prostate was treated with finasteride plus flutamide. Mean followup was 22 months.
Results:
Initial mean prostate specific antigen level was 42.9 ng./ml. At 3 and 6 months, the mean prostate specific antigen level was 3.6 ng./ml. and 2.9 ng./ml., respectively. The results appear durable at 24 months. Side effects were minimal, with 86% of the men maintaining sexual function.
Conclusions:
Finasteride plus flutamide should be considered in sexually active patients with minimal volume advanced prostate cancer.