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RET/PTC oncogene activation is an early event in thyroid carcinogenesis
G Viglietto1, G Chiappetta, F J Martinez-Tello
1Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Italy.
Oncogene
|September 21, 1995
Summary
RET/PTC oncogene activation is an early event in thyroid papillary carcinomas. This finding in occult thyroid cancers suggests it initiates the transformation process, impacting cancer development research.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- RET/PTC oncogene activation is observed in approximately 20% of human thyroid papillary carcinomas.
- The precise role of RET/PTC activation as an early or late event in thyroid carcinogenesis remains undetermined.
Purpose of the Study:
- To investigate whether RET/PTC oncogene activation is an early or late event in the development of thyroid papillary carcinomas.
- To determine the presence of RET/PTC activation in occult thyroid papillary carcinomas.
Main Methods:
- Utilized a combined immunohistochemical and reverse transcriptase-polymerase chain reaction (RT-PCR) based approach.
- Analyzed 26 cases of occult thyroid papillary carcinomas.
Main Results:
- RET/PTC activation was detected in 11 out of the 26 analyzed occult thyroid papillary carcinomas.
- The presence of RET/PTC activation in these early-stage tumors indicates its involvement early in the carcinogenic process.
Conclusions:
- RET/PTC oncogene activation represents an early event in the process of thyroid cell transformation and carcinogenesis.
- These findings contribute to understanding the molecular mechanisms underlying thyroid papillary carcinoma development.