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Retinoid X receptor alpha forms tetramers in solution

S Kersten1, D Kelleher, P Chambon

  • 1Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853-6301, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 12, 1995
PubMed
Summary

Retinoid X receptor alpha (RXR) forms stable homodimers and homotetramers in solution. Tetramer formation is high-affinity, becoming the dominant species above 70 nM, suggesting a role in gene transcription regulation.

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