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Bronchiolitis obliterans organizing pneumonia

G R Epler1

  • 1Department of Medicine, New England Baptist Hospital, Boston, MA 02120, USA.

Seminars in Respiratory Infections
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Bronchiolitis obliterans organizing pneumonia (BOOP) presents as a flu-like illness with lung infiltrates. Corticosteroid therapy often leads to resolution in idiopathic cases, but outcomes vary with associated conditions.

Area of Science:

  • Pulmonology
  • Pathology
  • Internal Medicine

Background:

  • Bronchiolitis obliterans organizing pneumonia (BOOP) is a significant cause of diffuse infiltrative lung disease.
  • It presents as a febrile, flu-like illness with lung infiltrates unresponsive to antibiotics.
  • BOOP is characterized by granulated tissue plugs in small airways extending into alveoli.

Purpose of the Study:

  • To discuss the diagnostic considerations of BOOP.
  • To outline the clinical presentation and pulmonary function findings.
  • To review associated conditions and treatment outcomes.

Main Methods:

  • Literature review of BOOP cases and associated conditions.
  • Analysis of clinical, radiological, and functional data.

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  • Evaluation of treatment responses, particularly to corticosteroids.

    • Main Results:

    • BOOP mimics pneumonia but is non-infectious.
    • Pulmonary function shows decreased vital capacity and diffusing capacity.
    • Corticosteroid therapy achieves complete resolution in 65-85% of idiopathic BOOP cases.

    Conclusions:

    • BOOP should be considered in the differential diagnosis of pneumonia mimics.
    • Treatment response to corticosteroids varies depending on underlying causes.
    • While often treatable, BOOP carries a risk of respiratory failure and death in a small percentage of patients.