Effect of arginine analogues on a fish pathogen, Aeromonas salmonicida

The effects of arginine analogues on a fish pathogen, Aeromonas salmonicida, were investigated. This organism proved to be resistant in various degrees to most arginine analogues tested but was found to be sensitive to arginine hydroxamate. Inhibition of growth by arginine hydroxamate was reversed by the addition of arginine to the bacterial culture. Incorporation of 14C from 14C-amino acids, namely, guanidoarginine, glutamate, asparate, alanine, isoleucine, serine, methyl-methionine, and cystine was affected.