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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Related Experiment Video

Updated: Jan 14, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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[Necrotizing pancreatitis]

H L Jakobsen1, F W Henriksen

  • 1Kirurgisk-gastroenterologisk afdeling D., Amtssygehuset i Gentofte.

Ugeskrift for Laeger
|October 2, 1995
PubMed
Summary
This summary is machine-generated.

Acute pancreatitis can become severe necrotizing pancreatitis, often fatal due to infected pancreatic necrosis. Prompt surgical intervention for infected necrosis is crucial for survival.

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Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
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Related Experiment Videos

Last Updated: Jan 14, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
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Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
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Area of Science:

  • Gastroenterology
  • Surgical Pathology

Context:

  • Acute pancreatitis is typically mild but can progress to severe necrotizing pancreatitis in 5-15% of cases.
  • Infected pancreatic necrosis is the primary cause of mortality in severe acute pancreatitis.
  • Contrast-enhanced computed tomography accurately identifies pancreatic necrosis.

Purpose:

  • To review the diagnosis and treatment of acute necrotizing pancreatitis, focusing on infected pancreatic necrosis.
  • To highlight the importance of differentiating sterile from infected necrosis.
  • To discuss current treatment strategies for infected pancreatic necrosis.

Summary:

  • Infected pancreatic necrosis mandates surgical intervention due to a near 100% mortality rate if untreated.
  • Continuous removal of pancreatic necrosis, often via open packing, is the goal of modern treatment.
  • The efficacy of prophylactic antibiotics and comparative trials for treatment modalities remain under investigation.

Impact:

  • Establishes infected pancreatic necrosis as a critical surgical emergency.
  • Emphasizes the role of advanced imaging in diagnosis.
  • Guides current management strategies while identifying areas for future research in acute pancreatitis.