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Promethazine toxicity in a seven-month-old Doberman pinscher
1Veterinary Medical Clinic, Alamogordo, NM 88310, USA.
Veterinary and Human Toxicology
|June 1, 1995
Summary
A Doberman Pinscher experienced severe toxicosis from a promethazine overdose. Prompt supportive care led to rapid recovery, highlighting the importance of accurate medication history in veterinary toxicology.
Area of Science:
- Veterinary Medicine
- Toxicology
- Pharmacology
Background:
- A 7-month-old Doberman Pinscher presented with critical signs including hypotension, tachycardia, mydriasis, and gastrointestinal distress.
- The dog was undergoing treatment for tonsillitis, with no initial history of toxin exposure provided by the owner.
Observation:
- Initial diagnostic efforts focused on supportive and non-specific toxicologic treatments due to the lack of a clear toxic insult.
- A significant clinical improvement was noted within 4 hours of initiating supportive care.
Findings:
- The dog's condition rapidly improved following supportive care, suggesting a reversible toxic event.
- The owner's wife later disclosed the administration of toxic levels of promethazine suppositories to manage vomiting associated with tonsillitis.
Implications:
- This case underscores the critical role of a comprehensive medication history in diagnosing toxicological emergencies in veterinary patients.
- Accidental overdose of common medications like promethazine can lead to severe clinical manifestations in dogs.
- Prompt recognition and supportive treatment are vital for managing adverse drug events and improving patient outcomes.