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Application of polylactic acid polymer in the treatment of acute maxillary sinusitis in rabbits
1Department of Otorhinolaryngology, Seoul National University College of Medicine, Korea.
Abstract:
To evaluate the therapeutic effects of topical antibiotic delivered by polylactic acid (PLA) polymer on paranasal sinusitis, we induced maxillary sinusitis in 32 New Zealand white rabbits by obstructing the maxillary sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae. The rabbits were divided into three groups: a control group (group 1) treated only by reopening the ostium, a group (group 2) treated by both reopening the ostium and injecting ampicillin (40 mg/kg/day), and a group (group 3) in which ampicillin in the PLA carrier (0.326 mg) was placed within the sinus after ostial patency was reestablished. The number of colony forming units (CFU) was lowest in group 3, followed by groups 2 and 1. Ampicillin concentration in the maxillary sinus secretion of group 3 was significantly higher than in group 2. The results suggest that treatment with PLA-ampicillin polymer may maintain high therapeutic concentrations of ampicillin in maxillary sinus secretion.
Insights
Polylactic acid (PLA) antibiotic delivery enhanced ampicillin concentration in rabbit sinusitis models. This novel PLA-ampicillin polymer shows potential for treating paranasal sinusitis effectively.
Area of Science:
- Otolaryngology
- Biomaterials Science
- Pharmacology
Background:
- Paranasal sinusitis is a common condition often requiring antibiotic treatment.
- Current antibiotic delivery methods may face challenges in achieving sustained therapeutic concentrations.
- Polylactic acid (PLA) is a biodegradable polymer with potential for controlled drug release.
Purpose of the Study:
- To evaluate the therapeutic efficacy of ampicillin delivered via a polylactic acid (PLA) polymer carrier for treating experimental paranasal sinusitis.
- To compare the effectiveness of PLA-delivered ampicillin with conventional ampicillin injection.
Main Methods:
- Maxillary sinusitis was induced in New Zealand white rabbits.
- Rabbits were divided into three groups: control (ostium reopening), ampicillin injection, and ampicillin-loaded PLA polymer.
- Bacterial load (colony forming units) and ampicillin concentration in sinus secretions were measured.
Main Results:
- The group treated with ampicillin-loaded PLA polymer exhibited the lowest bacterial load.
- Ampicillin concentrations in maxillary sinus secretions were significantly higher in the PLA-ampicillin group compared to the injection group.
- PLA-ampicillin treatment demonstrated superior bacterial clearance and drug concentration.
Conclusions:
- Topical delivery of ampicillin using a polylactic acid (PLA) polymer carrier can maintain high therapeutic concentrations in maxillary sinus secretions.
- PLA-based antibiotic delivery represents a promising strategy for enhancing the treatment of paranasal sinusitis.