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Drug utilization study during pregnancy

B Abdul Hadi1, J Török, G Mezey

  • 1Albert Szent-Györgyi Medical University, Faculty of Pharmacy, Debrecen.

Acta Pharmaceutica Hungarica
|May 1, 1995
PubMed
Summary
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Pregnancy drug use significantly increased from 15% before conception to 65.66% during pregnancy, with specific drug categories dominating each trimester. This highlights crucial patterns in medication intake for expectant mothers.

Area of Science:

  • Pharmacology
  • Obstetrics and Gynecology
  • Public Health

Background:

  • The thalidomide disaster significantly influenced drug registration policies in developed nations.
  • Understanding medication use during pregnancy is critical for maternal and fetal health.
  • Previous data on prescription drug prevalence throughout pregnancy is limited.

Purpose of the Study:

  • To quantify the rate of drug prescription during pregnancy.
  • To identify the most frequently used drug classes across different trimesters.
  • To analyze trends in medication use from pre-conception through the third trimester.

Main Methods:

  • A systematic hand search identified 2389 women delivering between September 1993 and June 1994.
  • Drug exposure data was collected via interviews post-delivery and hospital records.

Related Experiment Videos

  • Mothers' drug intake was cross-referenced with the Australian Classification of Drugs for pregnancy risks.

    • Main Results:

    • The overall prescription rate escalated from 15% in the two months prior to pregnancy to an average of 65.66% during pregnancy.
    • First trimester: Blood-forming drugs, vitamins, hormones, anxiolytics, antibiotics, and GI drugs were most common.
    • Second and third trimesters: Blood-forming drugs, vitamins, anti-infectives, anxiolytics, tocolytics, and antihypertensives were frequently used, with antithrombotics noted in the third trimester.

    Conclusions:

    • Medication use dramatically increases during pregnancy, necessitating careful monitoring.
    • Specific drug classes are consistently prevalent across trimesters, indicating common therapeutic needs.
    • Further research into the safety and necessity of these commonly prescribed drugs during pregnancy is warranted.