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Related Experiment Video

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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Interferon-alpha therapy for chronic myelogenous leukemia

M Wetzler¹, H Kantarjian, R Kurzrock

¹Department of Hematologic Oncology and Bone Marrow Transplantation, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

The American Journal of Medicine

|October 1, 1995

Summary

Interferon (IFN)-alpha therapy shows significant activity in chronic myelogenous leukemia (CML) patients, particularly at 5 million units/m2 daily. This treatment offers survival advantages and durable remissions, especially in early-stage CML.

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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Area of Science:

Hematology
Oncology
Pharmacology

Background:

Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm.
Interferon-alpha (IFN-alpha) has been investigated as a therapeutic agent for CML.

Purpose of the Study:

To review the efficacy and optimal use of IFN-alpha in CML management.
To report on the status of IFN-alpha therapy in CML patients.

Main Methods:

Systematic review of published literature.
MEDLINE database search for studies on IFN-alpha therapy in CML.

Main Results:

Optimal response observed with IFN-alpha at 5 million units (MU)/m2 per day.
IFN-alpha demonstrated superior cytogenetic response rates compared to chemotherapy.
Survival advantage noted in randomized trials for IFN-alpha treated patients.
IFN-alpha aids in maintaining remissions post-chemotherapy and bone marrow transplantation.

Conclusions:

IFN-alpha is an active agent in CML treatment, especially at 5 MU/m2 daily.
Early-stage, Philadelphia-positive CML patients achieve high hematologic and cytogenetic response rates.
IFN-alpha therapy offers a survival benefit in CML, independent of response depth.