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Follicular Hodgkin's disease
M Ashton-Key1, P A Thorpe, J P Allen
1Department of Histopathology, University College London Medical School, England.
The American Journal of Surgical Pathology
|November 1, 1995
Summary
Researchers identified Reed-Sternberg cells in Hodgkin's disease cases. These cells, expressing both Hodgkin's disease and B-cell markers, suggest a potential origin from mantle-zone B cells.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Hodgkin's disease (HD) is a lymphoid malignancy.
- Reed-Sternberg (RS) cells are the hallmark of HD.
- The cellular origin of RS cells remains debated.
Observation:
- Four cases of HD presented with purely follicular histology.
- RS cells in these cases showed classic/lacunar morphology.
- RS cells were CD30+, CD15+, CD20+, and CD79a+.
Findings:
- Follicles were composed of mantle-zone B cells enclosing RS cells.
- Follicle centers were atrophic and lacked RS cells.
- Review of nodular sclerosing HD revealed similar B-cell antigen expression in 66% of RS cells.
Implications:
- These findings suggest a possible derivation of some RS cells from B cells within the follicular mantle.
- This challenges traditional views on RS cell origin.
- Further research into B-cell involvement in HD pathogenesis is warranted.