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Peri-operative assessment of glomerular permeability
A R De Gaudio1, E Piazza, M G Barneschi
1Department of Anesthetics, University of Florence, Italy.
Anaesthesia
|September 1, 1995
Summary
Open abdominal surgery significantly increases microalbuminuria, indicating temporary kidney damage. This effect, a marker of systemic vascular permeability, resolves within 24 hours post-operation.
Area of Science:
- Nephrology
- Surgical Physiology
Background:
- Surgical trauma can increase glomerular permeability, a subclinical indicator of which is microalbuminuria.
- Microalbuminuria may reflect generalized systemic vascular permeability changes.
- Assessing microalbuminuria requires specialized tests like radioimmunoassay, not routine labs.
Purpose of the Study:
- To compare microalbuminuria levels in patients undergoing open abdominal surgery versus videolaparoscopic surgery.
- To investigate the relationship between surgical insult severity and glomerular permeability.
Main Methods:
- Measured microalbuminuria/creatinine ratio in two patient groups: open surgery (B) and laparoscopic surgery (A).
- Standardized anesthetic techniques and ensured similar surgery durations.
- Analyzed changes in microalbuminuria/creatinine ratio at 2 and 24 hours post-surgery.
Main Results:
- Open abdominal surgery (Group B) led to a significant increase (p < 0.01) in the microalbuminuria/urinary creatinine ratio.
- This increase was observed 2 hours post-surgery and normalized by 24 hours.
- A direct correlation was found between glomerular permeability and surgical insult severity during surgery.
Conclusions:
- Open abdominal surgery causes a transient increase in glomerular permeability, evidenced by microalbuminuria.
- Videolaparoscopic surgery did not show a significant increase in microalbuminuria.
- Microalbuminuria serves as a sensitive marker for surgical stress on kidney function.