Related Experiment Videos
[Sneddon syndrome. Report of 3 cases]
V A Zaccariotti1, L F Martins, V da Costa
1Instituto de Neurologia de Goiânia, Brasil.
Arquivos De Neuro-Psiquiatria
|March 1, 1995
Summary
Sneddon's syndrome involves neurological issues linked to skin discoloration. This rare condition, characterized by skin changes and potential strokes, should be considered in diagnosing cerebral infarcts, especially in younger individuals.
Area of Science:
- Neurology
- Dermatology
- Vascular Medicine
Background:
- Sneddon's syndrome is a rare condition characterized by neurological symptoms and skin manifestations like livedo reticularis.
- The underlying pathology involves the obliteration of arterioles, causing a distinctive skin appearance regardless of temperature.
Observation:
- Three cases of Sneddon's syndrome in Caucasian males (ages 7, 16, and 54) are presented.
- Neurological presentations included hemilateralized motor seizures, hemiparesis, and hemifacial seizures.
- Imaging revealed porencephalic areas, parasagittal infarcts, and multiple cortical infarcts with occlusions.
Findings:
- Skin biopsies consistently showed endothelial vascular hyperplasia.
- Only one patient tested positive for IgG antiphospholipid antibodies, suggesting varied underlying causes.
- Cerebral infarcts and neurological deficits were observed in all presented cases.
Implications:
- Sneddon's syndrome, though rare, is a significant consideration in the etiological investigation of cerebral infarcts, particularly in younger populations.
- Early recognition and diagnosis are crucial for managing neurological complications associated with this syndrome.
- Further research into the pathogenesis and diagnostic markers for Sneddon's syndrome is warranted.