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Nimodipine levels in breast milk
1Department of Neurosurgery, Auckland Public Hospital, New Zealand.
The Australian and New Zealand Journal of Surgery
|September 1, 1995
Summary
Nimodipine, used for subarachnoid hemorrhage, was detected in breast milk. Concentrations in milk were similar to the mother's plasma levels, providing crucial data for breastfeeding mothers.
Area of Science:
- Pharmacology
- Neonatal Medicine
- Neurocritical Care
Background:
- Subarachnoid hemorrhage (SAH) is a critical neurological condition often requiring nimodipine treatment.
- Nimodipine is a calcium channel blocker effective in preventing cerebral vasospasm post-SAH.
- Limited data exist regarding nimodipine transfer into human breast milk.
Observation:
- This study observed a lactating patient treated with nimodipine following aneurysm surgery for symptomatic arterial spasm.
- Breast milk samples were collected and analyzed to quantify nimodipine levels.
Findings:
- Nimodipine was detected in the breast milk of the lactating patient.
- The concentration of nimodipine in breast milk was found to be relatively similar to its concentration in the patient's plasma.
Implications:
- These findings provide the first evidence of nimodipine presence in breast milk.
- This information is vital for healthcare providers counseling breastfeeding mothers on nimodipine therapy.
- Further research may be warranted to assess potential infant exposure and outcomes.