Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Murine CD38: an immunoregulatory ectoenzyme

F Lund1, N Solvason, J C Grimaldi

  • 1DNAX Research Institute, Palo Alto, CA 94304, USA.

Immunology Today
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-effectiveness analysis of health tapestry, a complex primary care program for older adults: a post-hoc analysis.

BMC primary care·2024
Same author

Benralizumab: A novel treatment for the cutaneous features of paediatric eosinophilic granulomatosis with polyangiitis (pEGPA).

The Australasian journal of dermatology·2023
Same author

Author Correction: Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans.

Nature communications·2022
Same author

The Association Between Nursing Home Resident Characteristics and Transfers to the Emergency Department: A Population-Level Retrospective Cohort Study.

Journal of the American Medical Directors Association·2021
Same author

Uncovering Survivorship Bias in Longitudinal Mental Health Surveys During the COVID-19 Pandemic.

medRxiv : the preprint server for health sciences·2021
Same author

A data resource from concurrent intracranial stimulation and functional MRI of the human brain.

Scientific data·2020
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

This study reviews murine CD38, an enzyme on immune cells. It covers CD38 expression, its enzymatic function using NAD+, and how antibodies affect lymphocyte activity, including B-cell proliferation.

Area of Science:

  • Immunology
  • Biochemistry
  • Cell Biology

Background:

  • CD38 is an ectoenzyme found on various hematopoietic cells.
  • It plays a role in immune cell function and utilizes NAD+.

Purpose of the Study:

  • To summarize current knowledge on murine CD38.
  • To detail its expression, enzymatic activity, and signaling pathways.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of published research on CD38.

Main Results:

  • CD38 expression is widespread in hematopoietic cells.
  • Antibodies targeting CD38 can modulate lymphocyte functions, such as B-cell proliferation.
  • The enzymatic activity of CD38 involves NAD+.

Related Experiment Videos

Conclusions:

  • Murine CD38 is a key molecule in immune cell regulation.
  • Understanding CD38's pathways is crucial for immunology research.