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Serum gangliosides as endogenous immunomodulators

L D Bergelson1

  • 1School of Pharmacy, Hebrew University of Jerusalem, Ein Kerem, Israel.

Immunology Today
|October 1, 1995
PubMed
Summary

Gangliosides can suppress immune responses. Elevated levels in tumors and atherosclerosis suggest gangliosides may play a role in these diseases by interfering with low-density lipoprotein clearance and plaque formation.

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Area of Science:

  • Immunology
  • Biochemistry
  • Pathology

Background:

  • Gangliosides are known to suppress immune activities both in vitro and in vivo.
  • Increased ganglioside levels are observed in tumors, atherosclerotic aorta tissue, and sera of patients with cancer or atherosclerosis.

Purpose of the Study:

  • To propose a hypothesis on the role of gangliosides in atherogenesis and carcinogenesis.
  • To explore ganglioside-induced immunomodulation as a potential factor in disease development.

Main Methods:

  • Literature review and hypothesis formulation.
  • Analysis of existing data on ganglioside levels in disease states.

Main Results:

  • Gangliosides' immunomodulatory properties are established.
  • Elevated ganglioside concentrations correlate with tumor and atherosclerosis presence.

Conclusions:

  • Gangliosides may contribute to atherogenesis by hindering low-density lipoprotein (LDL) clearance.
  • Ganglioside-induced immunomodulation is proposed as a mechanism in carcinogenesis and plaque formation.

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