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Updated: Aug 11, 2026
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
Published on: July 6, 2014
Lack of magainin-like activity in human cervical tissue
K A Hansen1, J Kilianski, K Newhall
1Department of OB/GYN, Medical College of Georgia, Augusta 30912-3360.
Problem:
The cervix plays an integral role in innate immunity of the human reproductive tract. Magainins are antimicrobial and spermicidal peptides recently described in human submandibular glands. We investigated the human cervix for magainin-like peptides.
Method:
Histologic sections of frozen and paraffin embedded cervical tissue from nine subjects were separately incubated with two rabbit, polyclonal, anti-magainin antibodies (CB-2 and CB-7) to investigate for magainin-like activity in the human cervix.
Results:
There was no specific staining of cervical columnar cells within the endocervical canal or in the endocervical crypts. Magainin-like immunoreactivity in the human submandibular gland confirmed previous observations.
Conclusion:
Antigen related to magainin-like peptides were not discovered in the human cervix.
