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Related Experiment Videos

Biosensing with surface plasmon resonance--how it all started

B Liedberg1, C Nylander, I Lundström

  • 1Department of Physics and Measurement Technology, Linköping University, Sweden.

Biosensors & Bioelectronics
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Surface plasmon resonance (SPR) biosensing instrumentation has evolved significantly. Key advancements focus on the sample handling and sensing chip, enabling broader real-time biospecific interaction analysis beyond just immunosensing.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Surface plasmon resonance (SPR) emerged as a powerful technique for label-free biosensing.
  • Initial SPR setups were laboratory-based, requiring significant expertise and customization.
  • Commercialization aimed to simplify SPR applications, particularly for immunosensing.

Purpose of the Study:

  • To provide a historical perspective on the development of SPR for immunosensing.
  • To highlight critical differences between early SPR experiments and modern instrumentation.
  • To discuss the broader applicability of SPR instrumentation for real-time biospecific interaction analysis.

Main Methods:

  • Subjective historical account of SPR development.
  • Comparison of initial experimental setups with commercial SPR instruments.

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  • Emphasis on the importance of peripheral components like sensing chips and sample cells.

    • Main Results:

    • Identified key differences in SPR instrumentation evolution.
    • Stressed the crucial role of sample handling and sensing chip design for practical biosensing.
    • Demonstrated the versatility of SPR instrumentation beyond immunosensing.

    Conclusions:

    • SPR instrumentation is adaptable for general real-time biospecific interaction analysis.
    • The practical success of SPR biosensing relies heavily on system integration beyond the optical core.
    • SPR detection is one of many potential methods for advanced biosensing applications.