Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Target-independent pattern specification in the olfactory epithelium

S L Sullivan1, S Bohm, K J Ressler

  • 1Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Neuron
|October 1, 1995
PubMed
Summary

Mammalian odorant receptor (OR) maps in the olfactory epithelium and olfactory bulb develop independently. Early functional development in the epithelium may influence olfactory bulb patterning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fine mapping of PTSD GWAS reveals a role for amygdala <i>Foxp2</i> in regulation of fear and threat responses.

bioRxiv : the preprint server for biology·2026
Same author

Diverse clinical manifestations of Parvovirus B19 infections during the 2024 outbreak in Germany.

Infection·2025
Same author

Pop-up Langmuir probe diagnostic in the water cooled divertor of Wendelstein 7-X.

The Review of scientific instruments·2024
Same author

Quantification of patellar tendon strain and opportunities for personalized tendon loading during back squats.

Scientific reports·2023
Same author

Development and validation of a brief screener for posttraumatic stress disorder risk in emergency medical settings.

General hospital psychiatry·2023
Same author

Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood.

Epidemiology and psychiatric sciences·2023

Area of Science:

  • Neuroscience
  • Olfactory system development
  • Sensory receptor biology

Background:

  • Mammals utilize approximately 1000 odorant receptors (ORs) expressed in olfactory epithelium neurons.
  • Neurons expressing a specific OR are spatially zoned but randomly distributed within zones.
  • Axons of OR neurons form organized maps in the olfactory bulb.

Purpose of the Study:

  • To investigate the independent or linked development of olfactory epithelial and bulbar maps.
  • To examine the role of retrograde influences from the olfactory bulb on the epithelium.
  • To understand the onset of gene expression and patterning of ORs and sensory transduction molecules during mouse embryogenesis.

Main Methods:

  • Studied gene expression and patterning during mouse embryogenesis.

Related Experiment Videos

  • Analyzed olfactory development in mice lacking olfactory bulbs.

    • Main Results:

    • Evidence suggests independent development of epithelial and bulbar maps.
    • Early functional development in the olfactory epithelium was observed.
    • Findings indicate potential relevance to olfactory bulb pattern development.

    Conclusions:

    • The olfactory epithelial and bulbar maps appear to develop independently.
    • Early functional maturation of the olfactory epithelium may play a role in olfactory bulb organization.