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Evaluation of a first-line spectrophotometric screening test for increased faecal porphyrin concentration
F M Zuijderhoudt1, J Dorresteijn-de Bok, K te Velde
1Department of Clinical Chemistry, Deventer Ziekenhuis, The Netherlands.
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|May 1, 1995
Abstract:
We compared a spectrophotometric screening test measuring faecal porphyrin concentration with an HPLC method. There was a good overall correlation between both methods although some scatter was observed. ROC plot analysis of the screening test leads to a cut-off value of 35 nmol porphyrin per g faeces, wet weight with a sensitivity of 97% and a specificity of 96%. These results indicate that the screening test is quite useful for detection of increased total faecal porphyrin concentration, but less useful in accurate measurement of increased total faecal porphyrin concentration.