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In-vitro analyses of mechanisms of B-cell development
A Rolink1, P Ghia, U Grawunder
1Basel Institute for Immunology, Switzerland.
Seminars in Immunology
|June 1, 1995
Abstract:
B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.