The role of brahma and related proteins in transcription and development

The differential transcription of Drosophila homeotic genes is maintained by the Polycomb and trithorax groups of regulatory proteins, many of which are thought to modulate chromatin structure. During the past year, studies of a trithorax group member, brahma, and related yeast and human proteins have suggested that they are components of huge complexes that assist DNA-binding regulatory proteins to overcome the repressive effects of chromatin on transcription.