Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predictive experimental animal tumor models: a concept

A E Bogden, H J Esber

    National Cancer Institute Monograph
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Goralatide (AcSDKP), a negative growth regulator, protects the stem cell compartment during chemotherapy, enhancing the myelopoietic response to GM-CSF.

    International journal of cancer·1998
    Same author

    Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition.

    British journal of cancer·1997
    Same author

    Proliferative response of human prostate tumour xenografts to surgical trauma and the transurethral resection of the prostate controversy.

    British journal of cancer·1996
    Same author

    Evaluation of the systemic toxicity and pharmacokinetics of the immunoconjugate anti-B4-blocked ricin in non-human primates. Delivered by multiple bolus injections and by continuous infusion.

    International journal of immunopharmacology·1993
    Same author

    Systematic development of bombesin/gastrin-releasing peptide antagonists.

    Journal of the National Cancer Institute. Monographs·1992
    Same author

    Response of human lung tumor xenografts to treatment with a somatostatin analogue (Somatuline).

    Cancer research·1990
    Same journal

    Second cancer following cancer of the breast in Connecticut, 1935-82.

    National Cancer Institute monograph·1985
    Same journal

    Second cancer following cancer of the respiratory system in Connecticut, 1935-1982.

    National Cancer Institute monograph·1985
    Same journal

    Second cancer following cancer of the digestive system in Connecticut, 1935-82.

    National Cancer Institute monograph·1985
    Same journal

    Summary: multiple primary cancers in Denmark, 1943-80.

    National Cancer Institute monograph·1985
    Same journal

    Second cancer following lymphatic and hematopoietic cancers in Denmark, 1943-80.

    National Cancer Institute monograph·1985
    Same journal

    Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Denmark, 1943-80.

    National Cancer Institute monograph·1985
    See all related articles

    Selecting appropriate animal tumor models is crucial for advancing cancer research. A spectrum of well-defined models, rather than single instances, better predicts clinical responses, especially for immunotherapy development.

    Area of Science:

    • Oncology
    • Comparative Pathology
    • Translational Medicine

    Background:

    • Animal tumor models are essential tools in cancer research, but their predictive value varies.
    • Existing models often fail to capture the full spectrum of human disease heterogeneity.
    • The complexity of cancer necessitates a nuanced approach to model selection.

    Purpose of the Study:

    • To introduce a conceptual framework for classifying animal tumor models.
    • To emphasize the importance of selecting appropriate models for immunotherapy research.
    • To highlight the need for well-characterized preclinical systems.

    Main Methods:

    • Conceptual differentiation between organ-specific disease models and specific neoplasm class models.
    • Emphasis on using a 'block' of tumors reflecting a spectrum of growth patterns and reactivities.

    Related Experiment Videos

  • Discussion of model selection criteria for chemotherapy and radiation responsiveness.

    • Main Results:

    • No single animal tumor model can fully represent an entire disease entity.
    • A collection of models exhibiting diverse characteristics better mimics clinical variability.
    • The effectiveness of immunotherapy is contingent on the chosen preclinical models.

    Conclusions:

    • Well-defined and characterized animal tumor model systems are critical for accurate preclinical research.
    • The selection of a spectrum of models is superior to single models for predicting clinical outcomes.
    • This approach is particularly vital for the development of novel immunotherapies.