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Focal myositis: a clinicopathological study
C J Caldwell1, M Swash, J D Van der Walt
1Department of Morbid Anatomy, London Hospital Medical College, UK.
Neuromuscular Disorders : NMD
|July 1, 1995
Summary
Focal myositis, a rare benign condition, can mimic soft tissue sarcoma. This study details two cases, revealing a T-lymphocyte and macrophage infiltrate distinct from polymyositis.
Area of Science:
- Pathology
- Immunology
- Oncology
Background:
- Focal myositis is a rare, benign inflammatory condition.
- It can clinically mimic soft tissue sarcoma.
- Approximately 30 cases have been reported since 1977.
Observation:
- Two new cases of focal myositis were analyzed using immunocytochemistry and electron microscopy.
- Histology revealed a destructive inflammatory myopathy with regeneration.
- Micro-organism stains and electron microscopy for viral particles were negative.
Findings:
- Immunocytochemistry showed a cellular infiltrate of T-lymphocytes and macrophages.
- T-cells were predominantly CD4+.
- MHC class 1 and 2 antigen expression on inflammatory cells was occasional.
Implications:
- The findings differentiate focal myositis from polymyositis.
- Understanding the immunophenotype aids in differential diagnosis.
- Further clinicopathological correlations are discussed for accurate diagnosis.