Related Experiment Videos
Epiglottitis following preparation for allogeneic bone marrow transplantation
J C Murray1, J K Chiu, S R Dorfman
1Texas Children's Cancer Center, Texas Children's Hospital, Houston 77030, USA.
Bone Marrow Transplantation
|June 1, 1995
Summary
A 7-year-old boy experienced acute epiglottitis after high-dose chemotherapy and total body irradiation for bone marrow transplant. This airway complication is a newly reported early side effect of BMT preparation.
Area of Science:
- Hematology
- Oncology
- Pediatrics
Background:
- Allogeneic bone marrow transplantation (BMT) involves intensive preparative regimens.
- Common early complications include gastrointestinal issues and oropharyngeal mucositis.
Observation:
- A 7-year-old boy presented with acute, airway-threatening epiglottitis.
- This occurred following a preparative regimen of high-dose cytosine arabinoside and total body irradiation.
Findings:
- Acute epiglottitis is a previously unreported early complication of allogeneic BMT preparation.
- The patient's condition was likely multifactorial, stemming from combined chemotherapy and irradiation toxicity.
Implications:
- Clinicians should consider acute epiglottitis in the differential diagnosis of upper airway symptoms post-BMT preparation.
- Early recognition and management are crucial for patients undergoing BMT.