Asymmetric cell division in human leukemic promyelocytic cells (HL-60)

Small cells accounted for 8-9% of the human leukemic promyelocytic cells (HL-60). The diameter of the small cells was 8.44 microns, whereas that of the large cells, which were heterogeneous in cells size, was 11.0 microns. The small cells were produced from the large cells through asymmetric cell division, which was demonstrated by cloning experiments and by microscopy.