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Neutrophil hyper-reactivity after exercise-induced angina pectoris
I Ott1, F J Neumann, A Schömig
1First Medizinische Klinik, Technische Universität München, Germany.
Coronary Artery Disease
|July 1, 1995
Summary
Exercise-induced angina increases neutrophil activity, suggesting a link to myocardial ischemia. Successful angioplasty reduces this neutrophil hyper-reactivity, highlighting its role in exercise-related cardiac events.
Area of Science:
- Cardiology
- Immunology
- Exercise Physiology
Background:
- Physical exercise may increase myocardial infarction risk.
- Activated neutrophils are implicated in exercise-induced cardiac events.
Purpose of the Study:
- To investigate neutrophil function changes during exercise-induced angina.
- To assess the impact of percutaneous transluminal coronary angioplasty (PTCA) on these changes.
Main Methods:
- Symptom-limited bicycle ergometry in 15 stable angina patients before and after PTCA.
- Measurement of neutrophil superoxide anion production (SOP) and chemotactic mobility.
- Serial blood sampling to assess neutrophil counts.
Main Results:
- Exercise-induced angina before PTCA significantly increased neutrophil count, SOP, and chemotaxis.
- After successful PTCA, the increase in SOP and chemotaxis during exercise disappeared.
- Neutrophil count increase remained similar before and after PTCA.
Conclusions:
- Exercise-induced angina is associated with neutrophil hyper-reactivity.
- Myocardial ischemia is the likely cause of this neutrophil response.
- PTCA effectively mitigates exercise-induced neutrophil hyper-reactivity.