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Gut-derived mediators of multiple organ failure: platelet-activating factor and interleukin-6
W L Biffl1, E E Moore, F A Moore
1Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Centre, Colorado 80204, USA.
British Journal of Hospital Medicine
|August 5, 1995
Abstract:
Laboratory studies suggest that the postischaemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. Platelet-activating factor, generated by phospholipase A2, appears to be active in priming neutrophils in the gut. Interleukin-6 also appears to be elaborated by the postischaemic gut, but may be even more important in distant organs via promoting neutrophil-mediated organ dysfunction.