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Interferons: their role in clinical practice

R Ucar1, M Sanwo, K Ucar

  • 1Division of Allergy and Clinical Immunology, Harbor-UCLA Medical Center, Torrance, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|November 1, 1995
PubMed
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Interferons are established treatments for several human diseases, with ongoing research suggesting expanded therapeutic applications. This review covers their current uses, side effects, and the scientific basis for their effectiveness.

Area of Science:

  • Immunology and Virology
  • Biomedical Research

Background:

  • Interferons (IFNs) are crucial signaling proteins in the innate immune system.
  • Their discovery marked a significant advancement in understanding viral infections and immune responses.

Purpose of the Study:

  • To outline current clinical applications of interferons in treating human diseases.
  • To detail the known side effects associated with interferon therapy.
  • To provide background information on the rationale behind interferon use.

Main Methods:

  • Comprehensive literature searches on interferons from their discovery to the present.
  • Inclusion of English-language studies focusing on human applications.
  • Review of reference lists from recent scientific reviews and selected fundamental mechanism studies.

Related Experiment Videos

  • Consideration of clinical trial data and anecdotal evidence of human interferon use.

    • Main Results:

    • Interferons are currently approved and utilized for treating a variety of human medical conditions.
    • The review details established indications and observed side effects of interferon treatments.
    • Fundamental mechanisms and clinical trial outcomes support their therapeutic role.

    Conclusions:

    • Interferon therapy is a recognized and effective treatment modality for numerous conditions.
    • Future research is expected to broaden the therapeutic scope of interferons.
    • Continued investigation will likely uncover new applications and refine existing ones.