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[Hemodynamic effect of intrathecal clonidine]
L Rubin1, P Koeberlé, K Bachour
1Service d'Anesthésie-Réanimation chirurgicale, CHU Saint-Jacques, Besançon.
Cahiers D'Anesthesiologie
|January 1, 1995
Summary
Intrathecal clonidine combined with bupivacaine-morphine prolongs sensory and motor blocks. While it caused temporary hypotension, this was easily managed, with no other clonidine-related complications observed.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Intrathecal administration of bupivacaine and clonidine prolongs motor and sensory blocks.
- Common side effects include hypotension and bradycardia.
Purpose of the Study:
- To compare the effects of intrathecal bupivacaine-morphine versus clonidine-bupivacaine-morphine.
- To evaluate the safety and efficacy of adding clonidine to bupivacaine-morphine for spinal anesthesia.
Main Methods:
- Randomized comparison of two patient groups.
- Group 1: Intrathecal bupivacaine-morphine.
- Group 2: Intrathecal clonidine-bupivacaine-morphine.
Main Results:
- Clonidine group experienced a blood pressure decrease between 2 and 8 hours post-administration.
- The observed hypotension was independent of sympathetic blockade.
- Hypotension was effectively managed with intravenous ephedrine; no other clonidine complications occurred.
Conclusions:
- Intrathecal clonidine-bupivacaine-morphine provides prolonged sensory and motor blockade.
- Transient hypotension is a manageable side effect of intrathecal clonidine.
- Clonidine can be safely used in combination with bupivacaine-morphine for spinal anesthesia.