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Summary
Subungual squamous cell carcinoma is rare, with only 58 cases reported. Radiation therapy was a key predisposing factor in a recent series, and distal phalanx disarticulation was an effective treatment.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Subungual squamous cell carcinoma (SCC) is an uncommon malignancy.
- Few cases have been reported in medical literature.
- Predisposing factors include chronic trauma, infection, and notably, radiation therapy.
Purpose of the Study:
- To report on a series of patients with subungual SCC treated at a major cancer center.
- To review the literature on subungual SCC.
- To identify predisposing factors and evaluate treatment efficacy.
Main Methods:
- Retrospective review of twelve patients with subungual SCC treated over 27 years.
- Literature search for previously reported cases of subungual SCC.
- Analysis of predisposing factors and treatment outcomes.
Main Results:
- Twelve cases of subungual SCC were identified and treated.
- The study identified radiation therapy as a significant predisposing factor in their patient series.
- Literature review indicated a total of 58 reported cases globally.
- Disarticulation of the distal phalanx was an effective treatment modality for most patients.
Conclusions:
- Subungual SCC is a rare cancer with limited reported cases.
- Radiation therapy should be considered a significant risk factor.
- Distal phalanx disarticulation is a recommended and effective surgical treatment for subungual SCC.