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Subungual squamous cell carcinoma

F F Attiyeh, J Shah, R J Booher

    JAMA
    |January 19, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Subungual squamous cell carcinoma is rare, with only 58 cases reported. Radiation therapy was a key predisposing factor in a recent series, and distal phalanx disarticulation was an effective treatment.

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    Area of Science:

    • Oncology
    • Dermatology
    • Surgical Pathology

    Background:

    • Subungual squamous cell carcinoma (SCC) is an uncommon malignancy.
    • Few cases have been reported in medical literature.
    • Predisposing factors include chronic trauma, infection, and notably, radiation therapy.

    Purpose of the Study:

    • To report on a series of patients with subungual SCC treated at a major cancer center.
    • To review the literature on subungual SCC.
    • To identify predisposing factors and evaluate treatment efficacy.

    Main Methods:

    • Retrospective review of twelve patients with subungual SCC treated over 27 years.
    • Literature search for previously reported cases of subungual SCC.
    • Analysis of predisposing factors and treatment outcomes.

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    Main Results:

    • Twelve cases of subungual SCC were identified and treated.
    • The study identified radiation therapy as a significant predisposing factor in their patient series.
    • Literature review indicated a total of 58 reported cases globally.
    • Disarticulation of the distal phalanx was an effective treatment modality for most patients.

    Conclusions:

    • Subungual SCC is a rare cancer with limited reported cases.
    • Radiation therapy should be considered a significant risk factor.
    • Distal phalanx disarticulation is a recommended and effective surgical treatment for subungual SCC.