Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary ventricular fibrillation is associated with increased paced right ventricular electrogram fractionation

R C Saumarez1, S Heald, J Gill

  • 1Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK.

Circulation
|November 1, 1995
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse effects of amiodarone at low dose: plus ça change.

Journal of the American College of Cardiology·1997
Same author

Atrial premature beats preceding episodes of paroxysmal atrial fibrillation: factorial analysis of a prediction system.

Pacing and clinical electrophysiology : PACE·1997
Same author

Exercise-induced T-wave alternans as a marker of high risk in patients with hypertrophic cardiomyopathy.

Japanese circulation journal·1997
Same author

Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction.

Circulation·1997
Same author

Chlamydia pneumoniae and coronary heart disease.

BMJ (Clinical research ed.)·1997
Same author

Amiodarone after myocardial infarction: EMIAT and CAMIAT trials.

Lancet (London, England)·1997

Patients with primary ventricular fibrillation (VF) show prolonged conduction delays in fractionated electrograms, suggesting a reentrant substrate. This finding helps understand VF mechanisms in individuals without structural heart disease.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Arrhythmias

Background:

  • The mechanisms underlying spontaneous ventricular fibrillation (primary VF) in patients lacking structural heart disease remain unclear.
  • Previous research in hypertrophic cardiomyopathy suggested prolonged conduction of fractionated ventricular paced beats may indicate a reentrant substrate.
  • This study investigated whether similar abnormalities exist in patients with primary VF.

Purpose of the Study:

  • To determine if patients with primary VF exhibit prolonged conduction delays in fractionated electrograms.
  • To investigate the potential presence of a reentrant arrhythmic substrate in primary VF.

Main Methods:

  • Nine primary VF patients and seven control subjects underwent electrophysiological study.

Related Experiment Videos

  • Right ventricular pacing was performed at multiple sites using a decreasing extrastimulus coupling interval (S1S2).
  • Conduction delays of fractionated electrogram potentials were measured at other right ventricular sites to construct conduction curves.

    • Main Results:

    • Primary VF patients exhibited significantly increased electrogram duration compared to controls (13 ms vs. 4 ms).
    • The S1S2 interval at which delays increased was longer in VF patients (318 ms) than in controls (274 ms; P < .01).
    • No significant difference was found in the number of fractionated potentials between groups.

    Conclusions:

    • Patients with primary VF demonstrate increased delays in individual potentials within fractionated electrograms compared to controls.
    • These findings suggest a component of a reentrant arrhythmic substrate may be present in primary VF.
    • This identifies a potential electrophysiological abnormality contributing to primary VF.