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Updated: Aug 15, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
Organ-sparing treatment for closed spleen injuries in children
V M Rozinov1, S B Savel'ev, R A Keshishyan
1Scientific Research Institute of Paediatrics and Paediatric Surgery, Moscow, Russia.
Abstract:
The results of organ-saving treatment for 84 children with closed transcapsular spleen rupture were studied. Criteria for the stipulation of differential curative tactics were present. Twenty-five children were treated conservatively. In 57 patients, different endosurgical manipulations were done. Laparotomy was done in 5 patients, including 3 patients who primarily had endosurgical treatment. Long-term results were studied for 29 children. The followup period was from 3 months to 4 years. Investigators showed that recommended tactics helped save organs in > 90% of children with transcapular splenic injuries. The possibility of restoring splenic structure and functional activity and preventing hyposplenism was proven by orthotopic saving of injured spleens.
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